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doi: 10.1165/rcmb.2002-0258OC 35 BerginDAReevesEPMeleadyPHenryMMcElvaneyOJCarrollTPet al

Additionally, NCOA4 engages with autophagy components, such as microtubule-associated protein 1A/1B-light chain 3, which are integral to autophagosome assembly and the selective autophagic degradation of ferritin (49,90,91)

Mechanism-informed strategies therefore target sources and nodes rather than applying blanket antioxidants: source-targeted ROS amplification inside tumors (e.g., radiotherapy or certain chemotherapies combined with ferroptosis inducers and microenvironmental iron loading to accelerate lipid peroxidation) can overwhelm malignant buffers, while node inhibition (selective NOX isoforms, FSP1/CoQ rescue circuits, or lipid-peroxidation repair pathways) can re-sensitize resistant clones (Jiang et al