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Moreover, in an aquatic model, i.e., common carp, a therapeutic dose of Zn sulfate (ZnSO 4 ), equivalent to 1/5 of the predicted LC 50 (2.09 mg/L), facilitated wound closure by exerting antioxidant activity and upregulating healing-related genes, including TGF-1, COL11, VEGF-A, and FGF-7 [156]

Ndrepepa G, Colleran R, Kastrati A

3.2 Zebrafish inflammation models construct strategies Zebrafish inflammation models are commonly established through chemical, physical, and infection-based approaches, each presenting unique advantages for investigating the mechanisms of action of phytochemicals (Zanandrea et al., 2020)

Such substances are necessary for metabolism and therefore are essential nutrients to sustain life