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Per day, the average male needs between 400 to 420mg, and women need between 320 and 360, more if pregnant, but studies have found health benefits from taking between 125 to 600mg per day

Nrf2 not only increases the enzyme levels of both the oxidative and non-oxidative arms, but it also facilitates the utilization of ribose 5-phosphate for the purine nucleotide synthesis (Mitsuishi et al., 2012), which appears to maintain the ribose 5-phosphate concentration at a low level and efficiently divert glucose flux into purine nucleotide synthesis through both arms of the pentose phosphate pathway

That contrast explains why the two are used for different goals rather than swapped for one another

G-Protein-coupled receptor kinase activity in hypertension : increased vascular and lymphocyte G-protein receptor kinase-2 protein expression