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All mice used in this study were males

third-line treatment includes renal replacement therapy, ascites concentrated transfusion and liver transplantation

Mechanistically, we present the first direct evidence of a transcriptional negative regulatory relationship between Stat1 and Nrf2, with Crizotinib promoting this transcriptional activity, suggesting that inhibiting Stat1 could offer an intriguing intervention strategy

4.7 Glycyrrhizin and other hepatoprotective agents A variety of hepatoprotective agents are currently used in clinical practice, including silymarin, N-acetylcysteine (NAC), ursodeoxycholic acid (UDCA), as well as polyene phosphatidylcholine (PPC), bicyclol, S-adenosylmethionine (SAMe), and glucocorticoids