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Interestingly, both of pro-HGF and cleaved HGF can bind to c-MET with high affinity, but only cleaved HGF can activate c-MET signaling, indicating that proteolytic cleavage is critical for HGF-induced c-MET activation 9,10

Some of the key signs of low B12 to look out for include: Muscle weakness Numbness and tingling in the hands and feet Difficulty walking Nausea Weight loss Irritability Fatigue Rapid heart rate (7) One of the other tell-tale symptoms of a B12 deficiency is constant fatigue or being tired all the time, which can also manifest as sleep disturbances, including insomnia in some people, often requiring sleep medications

The institutional review board of Chonnam National University Hospital approved the study protocol (CNUH-EXP-2021-431)

This response was more pronounced in the brown-tef extracts compared to the ivory-tef accession analyzed in this study