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265 In addition, genetic factors, such as STAT3/STAT4 polymorphisms, contribute to the development of autoimmune diseases such as RA by impairing immune tolerance and increasing susceptibility to autoreactivity

These results were concluded from ifosfamide-induced hemorrhagic cystitis in a mouse model

Often times age becomes an unwanted variable to consider in these studies due to the time mice must spend on the high fat diet to start displaying disease phenotypes