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Infect Genet Evol 17:210215 Ramsey J, Mukhopadhyay S (2017) Disentangling the frames, the state of research on the alphavirus 6K and TF proteins

Among the various compounds synthesized, the alkyl-based PROTAC 73 stands out, capable of inducing in vitro a selective and potent proteasome-dependent degradation of the target protein (DC 50 value of 214 nM), resulting in a favorable antiproliferative effect (IC 50 value of 1.3 M) 128