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G2/M cell cycle arrest and downregulation of Nf-kB/m-TOR/PI3K/AKT pathway

This is clinically relevant, as IGF-I is generally less reliable of a biomarker for screening adults above 60 years with GHD and is a better screening and diagnostic biomarker in GHD in subjects with disease onset in childhood or early adulthood (86)

This means the GHK-Cu is delivered steadily into the dermis without the surface-level disruption that can trigger the uglies in water-based serums that dump the active all at once

Studies in animal models have shown an anorexigenic action of GIP receptor agonism [36] and a recent phase 1 clinical trial with a long-acting GIP RA found that repeated dosing for 4 weeks induced modest WL (1.9 to 3.1 kg vs