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501 Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the dysfunction of upper and lower motor neurons

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LC-MS/MS Quantitation For the LC-HRMS method, acetyl-CoA and other short-chain acyl-CoAs were analyzed as previously described (Frey et al ., 2016) using an Ultimate 3000 quaternary ultra-high performance liquid chromatograph coupled to a Q Exactive Plus mass spectrometer (Thermo Scientific), with modifications for a two-column setup

That is a different risk universe severe hypoglycemia, dosing errors, loss of consciousness, death