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As shown in the Number of trials and Number of patients columns in the table, antidepressants were overall poorly investigated in small RCTs and with low to moderate SMDs between drug and placebo (SMD (95% CI)

All data points shown in bar graphs and in animal data are distinct samples

Calcium homeostasis is maintained through a complex interplay between plasma membrane calcium channels, intracellular calcium stores, and calcium-binding proteins (Ji et al., 2002