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In schizophrenia, immune activation upregulates pro-inflammatory cytokines (e.g., IFN-, IL-1, TNF-), which activate indoleamine 2,3-dioxygenase (IDO) via both IFN- receptor (IFN-R)-dependent and independent pathways (e.g., synergistic action of TLR4, IL-1R, TNF-R) (215)