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Twenty-seven women and three men who fulfilled American College of Rheumatology criteria for FM, with serum calcifediol levels below 80 nmol/L (32 ng/mL) were included in a double-blind, placebo-controlled study

Ensure adequate hydration, particularly if you are exercising regularly or living in a hot climate

These inhibitors increase serotonin levels in the brain, thereby improving mood

Ethical and Practical Considerations: If your study involves a larger cohort where ease of administration is paramount, and you're willing to account for potentially lower or more variable bioavailability, an oral formulation might be explored