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Apixaban: Adverse effects of apixaban include bleeding gums, vomiting, gastrointestinal hemorrhage, hematochezia, hematoma, hemorrhage, elevated liver enzymes, hemorrhage of muscle, headache, extradural intracranial hemorrhage, intracranial hemorrhage, non-traumatic spinal subdural hematoma, menorrhagia, hemoptysis, bleeding from the nose, conjunctival hemorrhage, retinal hemorrhage, and hematuria (2)

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It is likely that the reduction of this interval is due to the tendency to anticipate treatments in the last year, in order to intervene when the synkinesis are still slight and thus allowing the injection of fewer units and fewer muscles