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Also, though used as a last resort, the spleen might be surgically removed in cases where the red blood cells are so affected that the spleen removes them from the blood too quickly for other treatments to compensate

PLOS One 11, e0165130

In some embodiments, the interval between two fixed doses may be about 4 days, about 5 days, about 6 days, about 7 days, about 8 days, about 9 days or about 10 days

Researchers have addressed these issues through various modifications, such as the improved Hummers method that replaces NaNO 3 with H 3 PO 4 and the Tour method that uses an H 2 SO 4 /H 3 PO 4 mixture with higher KMnO 4 concentrations to improve oxidation efficiency while minimizing toxic gas formation 25