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Since the microbiome contributes to systemic immunity and can metabolise certain drugs, this may represent an indirect mechanism affecting both host susceptibility to TB and the bioavailability of orally administered anti-TB agents (Fan et al., 2023

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Upon closer inspection, however, only a handful of genes were annotated with this KOG category (2132 genes, depending on the taxa), and most of these were not canonical immune response genes (for instance, no toll-like receptors, NF-KB-associated genes, immunoglobulins, tumor necrosis factors, or melanin pathway genes were among the 31 genes annotated with defense mechanisms in O

In accordance with v-raf/v-myc expressed characters, the metabolic and proliferation rate of in vitro BV-2 greatly exceeds that of other microglia [27, 36]