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Recently, cuproptosis in acute myeloid leukemia was shown to be initiated by inhibiting heme biosynthesis [53] , therefore it is conceivable that iron chelation limited heme to induce cuproptosis in the clinical trials of deferiprone

Garlic and onions are also rich in sulfur containing compounds that may help support glutathione production

HO-1 mediates catalytic breakdown of heme, a potent pro-oxidant and pro-inflammatory molecule 465