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Associations between the dietary food groups, defined for the PDI index, and characterised faecal metabolites were assessed through linear mixed-effects regression models (LMER), fitted using restricted maximum likelihood (REML) via the lme4 R package (v.1.1-33) and tested with lmerTest (v.3.1.3)

Subsequently, TMA is transported via the portal circulation to the liver where flavin monooxygenases (FMOs) catalyze the conversion of TMA into TMAO

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