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Compared with unipolar depression, bipolar depressed subjects had significantly decreased connectivity between pgACC and amygdala and dorsomedial thalamus (150) Moreover, a separate group of investigators reported a more intense activation of ventral striatal, thalamic, hippocampal, amygdala, caudate nucleus/putamen, vmPFC, ventrolateral PFC, and ACC in bipolar depressed individuals compared with MDD and a healthy control group, especially in response to mildly and intensely fearful and sad, and mildly happy expressions (104)

So the next time you hear of a big scientific retraction, take hope: it may be that the system is getting stronger

We ploughed all our energy into the program so there was no time left for the anxiety and fear of the future that had been filling my days

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