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doi: 10.1038/s41580-018-0074-2 256 ZengDHeSMaCWenYSongWXuQet al

Studies of model compounds have established a range of 6.0 - 7.0 for the intrinsic p K a of the histidine side chain

During this process, most electrons can be safely transferred from donor to acceptor molecules in various redox pathways

Although the effect of some ER-phagy pathways on sensory neuropathies suggests the importance of this process in the peripheral nervous system, it is difficult to know how important loss of this selective autophagy subtype is for the genesis of neurodegenerative diseases of the central nervous system