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Importantly, lactulose treatment improved low-grade cerebral edema in patients with CHE [58]

In addition, Ref(2)P is the Drosophila homologue of mammalian P62, which functions as a substrate of autophagy to deliver ubiquitinated protein into autophagosome [21]

Superoxide combines with NO to form peroxynitrite that oxidizes BH 4 and destabilizes eNOS to produce more superoxide 22, 24, 25 thus, further enhancing the development of oxidative stress

Intuitively, this would seem to be an obvious approach, but there are technical difficulties in compacting high concentrations of active and preventing premature release: no system has yet reached the market