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Yet, patients with severe trauma or burn injury lose the normal mucosal protection barrier due to inflammatory mediators affecting paracellular and transcellular transport processes [4, 71, 80]

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As BPC 157 revealed its benecial effects when used to treat full-thickness excisional wounds in genetically diabetic mice, it has been speculated that this activity results from the impact of the peptide on the expression of the immediate response gene (egr-1)