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Similar content being viewed by others Introduction Psoriasis is a common chronic inflammatory skin disorder affecting approximately 23% of the global population [1].It is clinically characterized by hyperproliferation of keratinocytes (KCs), epidermal thickening, dermal vascular dilation, and massive infiltration of immune cells [2,3,4].The classical pathogenic paradigm primarily involves dendritic cell (DC) activation, polarization of Th1/Th17 cells, and sustained activation of the IL-23/IL-17 axis, collectively contributing to a chronic inflammatory microenvironment [5,6,7,8](Fig

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These points make it quite clear why B12 shots are not the magic bullet for weight loss that many hope they will be