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The small intestine has lower acidity than the stomach

10.1038/sj.onc.1207517 Oncogene 36 DateI.TakagiN.TakagiK.KagoT.MatsumotoK.NakamuraT.et al (2004)

As study conducted by Parmley and Hyynen (2009) shows that humans have clusters of codons with low abundance cognate tRNA (rare cognate tRNA), hinting at novel mechanism of tissue-specific transcription regulation [27, 32]

Importantly, these side effects are most prominent during treatment initiation and dose escalation periods, with median durations of 8 days for nausea, 3 days for diarrhea, and 2 days for vomiting