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It was also reported for its beneficial effect in Phase III clinical trial for type 2 diabetes and stage 4 chronic kidney disease patients, where it was shown to improve the estimated glomerular filtration rate (GFR) ( , a nutritional supplement containing five natural Nrf2 activators such as bacosides, silymarin, withanolides, ECGC and curcumin has been shown to reduce oxidative stress and increase antioxidant enzymes SOD and catalase expression (Nelson et al., 2006)

Mild hyperhomocysteinemia increases brain acetylcholinesterase and proinflammatory cytokine levels in different tissues

doi: 10.1111/j.1365-2133.2007.07814.x [DOI] [PubMed] [Google Scholar] 35.Huh SY, Shin JW, Na JI, Huh CH, Youn SW, Park KC

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