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The extravasation and trafficking of leukocytes in and out of the brain are also influenced by factors that can be released from pericytes and endothelial cells [31]

Specifically, SOD facilitates the conversion of superoxide anions into hydrogen peroxide, which is subsequently broken down by CAT and GSH-Px

According to a 2023 review in Cureus, the bacteria can transition from their active, motile spirochete form into dormant, drug-tolerant round bodies, or aggregate into protective biofilm-like structures