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Additionally, some who take Metformin experience vitamin B12 deficiency , though its important to note that B12 deficiency may not be directly caused by Metformin

Oncol Lett 20:448454 Yan W, Song L, Wang H, Yang W, Hu L, Yang Y (2021) Extracellular vesicles carrying miRNA-181b-5p affects the malignant progression of acute lymphoblastic leukemia

8 , e85e91 (2021)

Its so common that patients often dont recognize the symptoms (bloating, irregular digestion, food sensitivities, brain fog) as gut-related until after treatment