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GLT-1 is not only expressed in astrocytes

This background pain may appear in up to 24%49% of patients, and may be described as burning, stinging, or pulsatile.22,23 The most recent data do not fully support the theory that continuous pain is the result of longstanding paroxysmal TN.23 While the underlying pathophysiological mechanism is not fully understood, it is believed to involve central sensitisation and damage to C fibres of the nerve root

Moreover, a comprehensive summary of the activation strategies of the GSH system is presented, where we mainly identify several promising herbal monomers, which may provide valuable guidelines for the exploration of new therapeutic approaches