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They are present at varying frequencies and can contribute significantly to the global burden of anaemia via clinically significant homozygous forms and the more common, usually clinically silent carrier forms 243 (Table 3)

Although astrocytes support homeostatic salubrious functions to neurons in a healthy brain, they can also become toxic to neurons in a neurodegenerative brain 1

The prevalence in younger patients is also increasing

This work was further supported by the UKs Experimental Arthritis Treatment Centre for Children (supported by Versus Arthritis, Alder Hey Childrens NHS Foundation Trust, the Alder Hey Charity, and the University of Liverpool) and partially carried out at the NIHR Alder Hey Clinical Research Facility