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Remodeling (Strengthening the Structure): For months (sometimes even years), the new tissue matures, strengthens, and tries to blend in with the surrounding area to minimize scarring

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Again, the effect of TNF- was less clear, as two polymorphisms indicated that genetically determined increased TNF- level (rs11465996 and rs361525) and one polymorphism indicated that decreased TNF- level (rs3804099) (along with decreased IL-1 and IL-6 levels) were associated with beneficial response