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(PubMed) Batra S, Sahu RP, Kandala PK, Srivastava SK

Particularly in tumor cells with active glycolysis, accumulated lactate stabilizes and increases the activity of proglycolytic transcription factors such as HIF-1 and c-Myc, as well as the expression of their downstream target genes, via lactylation, thereby forming a self-reinforcing positive feedback loop that further entrenches the glycolytic phenotype of tumors [78, 79]

In addition to adenosine receptor agonists and antagonists, drugs that target intracellular signaling moleculessuch as Ras proteins, G proteins, and the small GTPase Rhoare also being explored (94)

The therapy is generally a safe one and does not involve any risks as well as complications