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Targeting virulence: a new paradigm for antimicrobial therapy

doi: 10.1186/s12943-016-0526-2 93 YangFLiJDengHWangYLeiCWangQet al

Based on studies, the No Observed Adverse Effect Level (NOAEL) is established at 5 mg/kg/day in rats, indicating that doses up to this level do not produce any adverse effects

These effects force permanent cell cycle exit and disrupt immunosuppressive tumor microenvironment, translating synergistic efficacy against RB -proficient and RB -deficient TNBC, paving the way for new clinical trials to evaluate their clinical impact on patients with TNBC