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Relationship between intratumoral expression of genes coding for xenobiotic-metabolizing enzymes and benefit from adjuvant tamoxifen in estrogen receptor alpha-positive postmenopausal breast carcinoma

Introduction In nervous tissues, nitric oxide (NO ), a gaseous messenger with multiple important roles in metabolism and homeostasis of animal and plant tissues, is shown to have both neurotoxic and neuroprotective effects depending on such factors as its local concentration ( is tightly linked to metabolism of both proteinogenic and non-proteinogenic amino acids, because NO precursors are arginine (Arg) or homoarginine (hArg) (Figure 1)

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