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In summary, activation of NRF2 can effectively regulate the function of chondrocytes, synovial macrophages, synovial fibroblasts, and osteoclasts, thereby effectively inhibiting synovial inflammation, protecting cartilage and subchondral bone, alleviating joint pain, and serving as a potential target for treating OA

Glutathione injections, like infusions, involve administering glutathione directly into the bloodstream

Kang MC, Lee HG, Lee SH, Song KM, Kim HS, Kim S, Choi YS, Jeon YJ (2022) Sargassum norneri inhibits fat accumulation via up-regulation of thermogenesis in obese mice

Noxious Procedure, Medication and Assessment The assessment was conducted by measuring ECG recordings, serum enzymes, tro- ponin T, RNA extraction and RT-PCR (GAPDH, iNOS, eNOS and COX-2 mRNA levels genes), macro/microscopic lesion presentation, clinical presentation, echocardiography and oxidative stress