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Conversely, zinc deficiency or chelation of tissue zinc improves anti-tumor immunity and enhances responses to immunotherapies such as PD-1, particularly in melanoma models [328]

Such an imbalance can be the result of several factors: stress-induced over-production of free radicals, a lack of exogenous antioxidants in the diet, a failure of internal defence systems, or increased exposure to reactive species (through smoking, alcohol, pollution ) If it persists, oxidative stress can dramatically affect the bodys principal constituents cells, fatty acids, proteins (such as DNA), sugars contributing to the development of chronic health problems (1-2)