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Pathological studies have confirmed that the expression of the pro-apoptotic protein Bax is significantly upregulated in Lewy body-positive dopaminergic neurons of patients with PD (Bov et al., 2014)

Thus, clinical trials on polyphenols focusing on their potential use in clinical settings in patients with muscle fatigue and related syndrome need to be performed to determine their actual role in the improvement of fatigue

It forms a complex with cyclophilin, a cytoplasmic protein present in T-cells, that inhibits the activity of calcineurin, a calcium/calmodulin-dependent phosphatase

NAC was approved for the treatment of potentially hepatotoxic doses of acetaminophen and pulmonary complications of cystic fibrosis