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This effect could be attributed to the reduction in antioxidant capacity, as E6* expression diminished antioxidant enzymes such as superoxide dismutase isoform 2 (SOD2) and glutathione peroxidase (GPx) [12]

doi: 10.1016/0076-6879(90)86093-B

3.2.5 Effects of in vivo metallodrug transformation The metabolism and transformation of metallodrugs in the body not only influence their therapeutic efficacy but also their potential toxicity (Sava et al., 2002)