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doi: 10.3390/plants11081091

Inflammatory cytokines such as IL-1 downregulate occludin expression selectively in vitro and in vivo

doi:10.3390/antiox11010154 Sp N, Kang DY, Kim DH, et al

It is possible that betaine could be an intermediate in the metabolism of choline to TMA which in theory can occur via the aldehyde/choline dehydrogenase /betaine reductase pathway