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Early Clinical Development Initial clinical studies focused on evaluating safety, tolerability, pharmacokinetics, and biological activity

Dietary Drift As side effects diminish over the first few months, eating patterns may gradually drift back toward pre-treatment habits

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A pan-FGFR inhibitor, BGJ398 (Novartis), was prepared in an acetic acid buffer (pH 4.6) for 10 min, followed by mixing with PEG300 (50% of final volume) using vortex