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In the context of increased tibial slope, chronic activation of stress-responsive pathways can lead to an imbalance between ECM synthesis and degradation, further compromising the ligaments integrity

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Within the latter family, two primary receptors are of paramount importance: RIG-I, which recognizes 5-triphosphorylated or diphosphorylated single-stranded RNA (ssRNA) and acts as the main cytosolic RNA sensor [215, 216], and MDA5, which recognizes viral RNA replicating in the cytoplasm [217, 218]

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