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As an example, when cells are under hypoxic stress, glutamine-derived -KG is used to stimulate lipids synthesis (150)

Age-related hearing loss (presbycusis) is also an attributed cause of hearing loss in humans, although it is debated whether presbycusis is more closely related to long-term noise exposure or the degeneration of hearing structures due to aging

Pharmaceuticals 15 , 370 (2022)

Environ Toxicol Chem 25:7286 McKim JM, Nichols JW (1994) Use of physiologically based toxicokinetic models in a mechanistic approach to aquatic toxicology