intracranial hypertension glutathione Paediatric Idiopathic Intracranial Hypertension (IIH)—A

Aberrant cGAS-STING activation leads to excessive and sustained production of type I interferon, which mediates local or systemic inflammation and is thus involved in the development of many inflammatory disease processes (92)

At the N-terminus, it has its catalytic active site with a Rossmann dinucleotide fold interacting with the 2 OH of the final nucleotide of tRNA Gln (A76), while the C-terminus interacts with the tRNAs anti-codon loop

Unfortunately, glutathione is not absorbed well by the body after oral administration, limiting its clinical use in humans

10.1038/ncomms14338 97 PanB.LiJ.ParajuliN.TianZ.WuP.LewnoM