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245 Initially, during fasting, signaling pathways mediated by mTOR, insulin, and leptin are suppressed

Nevertheless, it has been shown that mitochondrial proteins are highly sensitive to redox stress due to the slightly higher pH in mitochondria, which favours the reactivity of cysteine thiolates 39

Furthermore, a study on dietary antioxidantssuggests that the majority of cases of ED are directly related to oxidative stress caused by free radicals