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Moreover, devimistat effectively inhibited the activity of PDH and -KGDH, restricted TCA cycle flux, and impeded the in vitro and in vivo growth of GC cells expressing either WT DLD or the hyperacetylation-mimicking DLD K430Q mutant, demonstrating its broad applicability (Supplementary Fig

374,375,376 However, subsequent studies demonstrated that this rejuvenation effect is attributed to noncellular factors present in the blood rather than the cells themselves

This was confirmed by the obtained results of lower CAT activity and higher plasma MDA concentration in the study group as compared with the control

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