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FIGURE 1 3.1.1.3 Cancer metastasis and ROS Excessive level of ROS leads to metastasis via the stimulation of mitogen-activated protein kinase (MAPK), and phosphoinositide-3-kinase regulatory subunit/AKT serine/threonine kinases/mechanistic target of rapamycin kinase (PI2K/Akt/mTOR) signaling pathways that directs the activation of downstream metalloproteinase 9 (MMP9), metalloproteinase 2 (MMP2), SNAIL enzymes which initiate epithelial-mesenchymal transition (EMT) to metastasis (Deepika et al., 2013)

Anti-CHAC1 exosomes for nose-to-brain delivery of miR-760-3p in cerebral ischemia/reperfusion injury mice inhibiting neuron ferroptosis

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