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Biomechanical stressing and microdamage at entheses or synovio-entheseal complex, independent of adaptive immune response, can lead to autoinflammatory response, defined as a self-directed inflammation where local factors at sites predisposed to disease initiate activation of innate immune cells, including macrophages and neutrophils

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Interestingly, they noted that the increased dose of probiotics did not directly influence hemoglobin and hematocrit levels ( L

To cope with the elevated oxidative stress they generate, cancer cells enhance their antioxidant capacity, largely through sustained activation of the transcription factor NRF2 often driven by mutations in its negative regulator KEAP1