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Acetylcarnitine, on the other hand, affects the epigenetic regulation of metabotropic glutamate type 2 receptors (mGluR2), negatively modulating neurotransmitter release and producing rapid and long-lasting antidepressant effects (demonstrated by forced swim tests, sucrose preference tests) in Flinders Sensitive Line rats and in mice exposed to chronic unpredictable stress, which model genetic and environmentally induced depression, respectively [92]

High levels of the transcription factor NRF2 can induce metabolic reprogramming in dormant tumor cells, re-establishing redox homeostasis and de novo synthesis of nucleotides, accelerating the activation of tumor cells and tumor recurrence