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This metabolic shift is characterized by upregulation of rate-limiting glycolytic enzymes such as pyruvate kinase M2 isoform (PKM2) and hexokinase (HK), leading to elevated production of glycolytic end-products, including pyruvate and lactate ( ex vivo , and increased activities of HK, PKM2, and lactate dehydrogenase (LDH) have been reported in mouse models of AKI ( Collectively, these findings indicate a metabolic shift from FAO to glycolysis in TECs during AKI

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Safety of Epidural Corticosteroid Injections