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doi: 10.1016/j.exer.2016.06.018 47 TimmonsGACarrollRGOSiorainJRCervantes-SilvaMPFaganLECoxSLet al

Pediatrics 2001;108:776-89

This complex process involves a series of sequential steps, beginning with the detachment of cancer cells from the primary tumor, followed by their migration through the extracellular matrix (ECM) and invasion into surrounding tissues and blood vessels