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Although there were only marginal increases in intracellular GSSG levels ( P = 0.064), IL-13 increased extracellular (apical supernatant) GSSG ( P = 0.009), while lowering both GSH ( P = 0.012) and GSH:GSSG ( P = 0.006

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Notably, this approach identified previously reported serotonylation targets, such as GAPDH 23 and histone H3 18 , validating the robustness and specificity of our methodology (Fig