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Given the diversity of cell types in the mammalian brain, certain genomic loci may exhibit bipolar DNA methylation pattern, meaning that these loci are hypermethylated in some cell subtypes and hypomethylated in others, reflecting the functional diversity across different cell populations (Sun et al., 2016)

For example, boosting NAD + through NR administration could confer anti-inflammatory effects on tissue macrophages, in which NR supplementation attenuated the type I IFN signaling pathway, an important myeloid regulatory program, through the increased inosine level and the subsequent suppression of autophagy [97]

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